Confederacy of Dunces by John Kennedy Toole

A Confederacy of Dunces is an American comic masterpiece. John Kennedy Toole's hero is one Ignatius J. Reilly, "huge, obese, fractious, fastidious, a latter-day Gargantua, a Don Quixote of the French Quarter. His story bursts with wholly original characters, denizens of New Orleans' lower depths, incredibly true-to-life dialogue, and the zaniest series of high and low comic adventures."